Focusing on What Matters Most

1.1 Wresting from nature future human evolution

Biotechnology now makes it possible to wrest from nature future human evolution. This is the most far-reaching development in history since humans branched off from other primates some million years ago. The central challenge confronting humanity now is what ought to be done with this awesome power.

1.2 The prospect of genetic bifurcation of humanity

In the West, there is a recoil from using this gene-editing technology in order to go beyond disease prevention to enhancement and to go beyond treatment of an individual to make genetic modifications heritable. In China, in contrast, this technology is considered to be capable of enhancing the human condition. The initial focus appears to be on enhancing intelligence, which seems to be a long-standing cultural focus (see figure 1.2). If China would focus on genetically improving intelligence, then within 4-5 generations in a century, the genetic divergence would be substantial and perhaps insurmountable. By the end of the century China would be in the position of winning an undeclared world war. Unlike world wars of the past, this one would be inherently irreversible.

1.3 Innate human commonalities are the basis of human nature and conduct

Recent neuroscientific findings have proved Darwin right that humans possess both biological and psychological innate attributes. Thus, there exist innate commonalities of needs and desires that constitute the factual basis for human nature and conduct. As a consequence, ethical systems must be based on universals of human nature. Similarly, legal systems ought to be based on the doctrine of natural law rather than positive law. [66] Empiricism is the basis of the present-day theories of knowledge. The most basic assumption of Empiricism is the denial of the existence of innate sensations and cognitions, concluding that the newborn cannot have knowledge of the world prior to personal experience. We now know that the assumption and conclusion are factually false. These assumptions have contributed to the choice of ethical and legal systems in the West that are relativistic rather than universal. These relativistic systems do not provide common ground to address long-term global issues with differing cultures’ ethical and legal systems, such as making heritable enhancements to the human genome.

1.4 Updating the foundation of knowledge

It is therefore now necessary to acknowledge the scientific findings and update the foundation of knowledge. It will remain necessary to revise ethical and legal systems to make them universal rather than relativistic. These systems will have differences across cultures and countries but must be viewed relative to a common denominator. The ability to make heritable enhancements in the human genome is the most important challenge confronting humanity today. Meeting that challenge, in turn, makes updating the foundation of knowledge, ethics, legal systems, and public policy a matter of priority.

1.5 The philosophic community

It is for the philosophic community to take on the challenge of bringing the foundation of knowledge up-to- date. It is a unique opportunity for philosophy to take a central role in advancing the knowledge enterprise. However, setting aside 300 years of epistemological legacy by accepting the neuroscientific findings that prove correct Darwin’s theory of evolution in regard to biological and psychological attributes will take time. Max Planck noted that acceptance of a new paradigm often involves generational transition. In this case, it is in the public interest to avoid any further delay. In fact, it may prove to be a survival imperative.

The percentage of Caucasian and Asian students in Stuyvesant High School in New york. Adapted from July 20, 2014 article in the New York Post by Dennis Saffran.

A Note About The New Foundation of Knowledge

Being conscious is the central fact of human experience. Yet, it is not presently known what consciousness is and what it does. For example, Physicalism, the currently dominant theory of knowledge takes the position that the non-conscious brain can do anything that the conscious brain can do. Artificial intelligence (AI) takes a similar view, that the digital computer can do anything that the conscious brain can do. In short, consciousness is deemed to be an evolutionary fluke. This book shows that the innateness of mental faculties is an empirical fact and establishes the reality and centrality of consciousness. Physics is considered to be the most basic science. However, how we get to know the physical world is a more basic question. Until recently, the central issue was this: are sensations innate, or they imported from the senses into the brain? We now know that sensations are innate. They are not imported into the brain from the senses or from the outside world through the senses. Consider sound. Recently, children born deaf have been made to experience sensations of sound by the electrical stimulation of hearing-related brain areas. This fact proves that the sensation of sound is innate and that it is not a property of air vibration. Present-day neuroscience takes all sensations to be innate. Thus, the direct electrical stimulation of vision-related brain areas in children born blind would elicit sensations of light. I expect such experiments to take place within five years. It would prove that the sensation of light is innate, private, and not a property of electromagnetic radiation. For the last 300 years, theories of knowledge are based on the directly opposite assumption that no sensation is innate. It is now necessary to bring the foundation of knowledge up to date.

 Available on Amazon .  

Available on Amazon.

Two related patents for sale (Identifying the NCC)

In 2001 I filed with the United States Patent Office a patent application for concepts and methods for identifying brain cells that determine the qualitative aspect of simplest sensations. It resulted in two granted patents.

The first patent, Number 7,680,602 titled Concepts and methods for identifying brail correlates of elementary mental states was granted in 2010. It involves identifying locus-specific cells that determine the qualitative aspect of the simplest sensations. The second patent, Number 8,112,260 titled Methods for identifying protein specificity of brain cells that evoke a given mental state that does not contain smaller constituents was granted in 2012. It involves identifying methods for identifying the unique protein specificity of the so-identified cells.

The three basic tenets on which the patents are based are:

  1. The simplest sensations are innate and are evoked by the brain.
  2. Their qualitative aspects are determined by locus-specific cells.
  3. The primary determinant of the intrinsic function of a cell is its proteome.

I review the involved conceptual framework in The New Foundation of Knowledge (2017).  

I am now offering these two patents for sale. I would be willing to provide, for a time, consulting on how these patents can be the basis for additional related patent applications.

A 3-Part Project – Each Deserving its Own Nobel Prize

1. The challenge

Neuroscience has established that sensations, including those by which the physical world is knowable, are innate. The implication that the sensation of color is innate and evoked by the brain, rather than received from the eyes or being an aspect of the electromagnetic spectrum, is counterintuitive. More jarring still is that the same applies to the sensation of light. Commonsense rebels against the notion that the sensation of light is innate and as such private, or phenomenal.

Even Newton, who conceded that experienced color is brought about by the “sensorium” and contending that achromatic white light is a combination of colors, could not bring himself to make explicit the conclusion that the sensation of light, like that of color, is “sensorium”- dependent. This reluctance or inability to make explicit the implication that since the sensations of color are innate and phenomenal, so are the sensations of brightness and lightness.

This is the very reason that identifying the molecular and cellular determinants of the sensation of light (i.e. applying the notion of neural correlates of consciousness to the sensation of light) will have a shocking impact on the knowledge enterprise.

2. The three phases of the undertaking

2.1. First, it is necessary to prove the sensation of light is innate. The direct electrical stimulation of the visual cortex of persons that are not cortically blind elicits sensations of light (phosphenes). This has been demonstrated in normally seeing persons and in persons who lost their vision. It remains to be demonstrated that the same is true in the case of born blind children.

Such a procedure is both possible and necessary in order to provide such children with cortical visual prosthetics. Such prosthetics have been developed (Dobelle 2000) and confirming that the electrical stimulation of the visual cortex does elicit the sensations of light in persons who lost their vision. Recently I urged some organizations to test such cortical visual prostheses on children born blind. I believe that by 2020 such tests would confirm that these cortical visual prostheses elicit sensations of light in the born blind.

2.2. Next, it is necessary to identify the locus-specific cells of interest. It is known that a lesion in the color area in the visual cortex can leave a person completely colorblind but leave intact the sensation of light and dark as well as visual sensation of motion direction. Current literature does not yet identify the brain locus that evokes the sensation of light

The following conceptual framework resolves this issue, making it accessible to empirical verification:  any cells or circuits that create an illusion of a given sensation are those that evoke that sensation under normal circumstances.

Specifically, it is necessary to identify in the visual cortex locus-specific cells that are selectively activated if, and only if, the subject experiences a sensation of light through external or direct electrical stimulation. Anna Wang Roe, et al (2005) identified cells in the thin stripes of visual area V2 that are directly involved in producing a brightness illusion. Hence, visual area V2 is one of the areas of the visual cortex containing cells and circuits that evoke a sensation of light.

2.3. A cell type’s proteome is a determinant of intrinsic function. The morphology of a neuron, as in any cell type of a given organism, is determined primarily by its continually-expressed proteins. Thus, here exists a unique proteome characteristic of cells that evoke the sensation of light. Present day single-cell sequencing techniques make it possible to identify the unique proteome of the cells of interest.

3. Conclusion

I believe that meeting the challenge of any of the three phases would justify a Nobel Prize. Meeting all three phases would bring to an end the era that began with Locke and Hume, based on the denial of innate sensations emotions and cognitions, and mark the advent of a new era regarding the nature of consciousness.